abstract：:Saccharides used in clinical nutrients and the hyperglycemia status may facilitate tumor growth and aggravate cancer patients' outcome. As glucose, fructose and maltodextrin are widely used in clinical practice, various effects on tumor progress among them remain unknown. Six kinds of tumor cell lines were included in...

journal_title：Biochemical and biophysical research communications

authors： Yu C,Lv B,Min S,Ren L,Yu J

更新日期：2020-05-07 00:00:00

abstract：:Yeast cell viability and concentration are the crucial factors affecting product quality in food industry and bio-fuel production, as well as the evaluation basis for environmental toxic compounds. To overcome the drawbacks of existing methods, including high error, false positive and low automation, we propose a high...

journal_title：Biochemical and biophysical research communications

authors： Li G,Wei M,Sun J,Zhang Y,Zhang R

更新日期：2020-05-07 00:00:00

abstract：:The levels of the anti-aging protein α-Klotho, in its soluble form (s-Klotho), are depressed in the circulation of patients with type 1 diabetes (T1D) or type 2 diabetes (T2D). Gene transfer experiments have suggested a protective role for β-cell specific expression of α-Klotho in murine models of T1D and T1D, but the...

journal_title：Biochemical and biophysical research communications

authors： Prud'homme GJ,Glinka Y,Kurt M,Liu W,Wang Q

更新日期：2020-05-07 00:00:00

abstract：:Uveitis is a sight-threatening intraocular inflammatory disease that accounts for almost 10% of blindness worldwide. NF-κB signaling plays pivotal roles in inflammatory diseases. We have reported that IMD-0354, which inhibits NF-κB signaling via selective blockade of IKK-β, suppresses inflammation in several ocular di...

journal_title：Biochemical and biophysical research communications

authors： Liu Y,Kitaichi N,Wu D,Hase K,Satoh M,Iwata D,Namba K,Kanda A,Noda K,Itai A,Iwabuchi K,Ishida S

更新日期：2020-05-07 00:00:00

abstract：:Calcium/calmodulin-dependent protein kinase (CCaMK) has been shown to play important roles in brassinosteroid (BR)-induced antioxidant defense and enhancing the tolerance of plants to drought stress. The autophosphorylation of CCaMK is a key step for the activation of CCaMK, thus promoting substrate phosphorylation. H...

journal_title：Biochemical and biophysical research communications

authors： Liu L,Han T,Liu W,Han G,Di P,Yu X,Yan J,Zhang A

更新日期：2020-05-07 00:00:00

abstract：BACKGROUND:RapaLink-1 is a third generation mammalian target of rapamycin (mTOR) inhibitor and displays superior inhibitory effect on mTOR complex 1 (mTORC1). mTOR pathway is known to block autophagy and inhibition of it can protect thrombosis-related diseases including atherosclerosis, antiphospholipid syndrome (APS) ...

journal_title：Biochemical and biophysical research communications

authors： Mu F,Jiang Y,Ao F,Wu H,You Q,Chen Z

更新日期：2020-04-30 00:00:00

abstract：:Adherens junction-associated protein-1 (AJAP1), also called SHREW1, was first discovered as a novel component of adherens junctions in 2004. In later studies, AJAP1 was found to suppress invasion and predict recurrence of some tumors. Apart from its function as a putative tumor suppressor, AJAP1 is still poorly unders...

journal_title：Biochemical and biophysical research communications

authors： Zhang M,Zhou X,Jiang W,Li M,Zhou R,Zhou S

更新日期：2020-04-16 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) represents a global health problem. Impaired autophagy has been implicated in the pathogenesis of NAFLD, and CD147 is recognized to regulate lipid metabolism in a variety of cell types. This study was initiated with the aim to identify molecular makers expressed in hepatocytes ...

journal_title：Biochemical and biophysical research communications

authors： Lou J,Li C,Li ZS,Zhang T,Chen ZN,Bian H

更新日期：2020-04-16 00:00:00

abstract：:Cancer-induced pain (CIP) is a kind of chronic pain that occurs during cancer progression over time. However, the mechanisms are largely unknown, and clinical treatment remains challenging. LncRNAs have been reported to play critical roles in various biological processes, including chronic pain. The aim of our study w...

journal_title：Biochemical and biophysical research communications

authors： Sun RM,Wei J,Wang SS,Xu GY,Jiang GQ

更新日期：2020-04-16 00:00:00

abstract：:Wheat germ derivatives have been shown to inhibit inflammation-related diseases. In this study, a small peptide (YDWPGGRN) isolated from wheat germ was used to study its anti-inflammatory activity and its application in skin wound healing. Both the in vitro and in vivo results clearly showed that YDWPGGRN significantl...

journal_title：Biochemical and biophysical research communications

authors： Sui H,Wang F,Weng Z,Song H,Fang Y,Tang X,Shen X

更新日期：2020-04-16 00:00:00

abstract：:Amyloid β (Aβ) oligomers may be a real culprit in the pathogenesis of Alzheimer's disease (AD); therefore, the elimination of these toxic oligomers may be of great significance for AD therapy. Autophagy is the catabolic process by which lysosomes degrade cytosolic components, and heat shock cognate 70 kDa protein (Hsc...

journal_title：Biochemical and biophysical research communications

authors： Dou J,Su P,Xu C,Wen Z,Mao Z,Li W

更新日期：2020-04-16 00:00:00

abstract：:The carcinogenic function of arachidonate lipoxygenase12 (Alox12) has been reported in various cancers. However, little is known on the role of Alox12 in lung cancer. Here, we demonstrate that Alox12 is upregulated and contributes to biological activities of lung cancer through multiple mechanisms. We found that Alox1...

journal_title：Biochemical and biophysical research communications

authors： Chen J,Tong W,Liao M,Chen D

更新日期：2020-04-16 00:00:00

abstract：:Post-translational modifications (PTMs) play pivotal roles in controlling the stability and activity of the tumor suppressor p53 in response to distinct stressors. Here we report an unexpected finding of a short chain fatty acid modification of p53 in human cells. Crotonic acid (CA) treatment induces p53 crotonylation...

journal_title：Biochemical and biophysical research communications

authors： Liao P,Bhattarai N,Cao B,Zhou X,Jung JH,Damera K,Fuselier TT,Thareja S,Wimley WC,Wang B,Zeng SX,Lu H

更新日期：2020-04-09 00:00:00

abstract：:Inflammatory signals associated with cardiac diseases trigger trans-differentiation of cardiac fibroblasts to cardiac myofibroblasts. Cardiac myofibroblasts are the main cell type involved in the development of cardiac fibrosis, a diffuse and disproportionate accumulation of collagen in the myocardium. Although the ro...

journal_title：Biochemical and biophysical research communications

authors： Villa M,Cerda-Opazo P,Jimenez-Gallegos D,Garrido-Moreno V,Chiong M,Quest AF,Toledo J,Garcia L

更新日期：2020-04-09 00:00:00

abstract：:Deformation of vacuolar membranes mediated by endosomal sorting complex required for transport (ESCRT) is necessary for microautophagy. Target of rapamycin complex 1 (TORC1) protein kinase negatively regulates ESCRT-0 (Vps27-Hse1) recruitment onto vacuolar membranes and microautophagy induction. However, whether and h...

journal_title：Biochemical and biophysical research communications

authors： Sharmin T,Morshed S,Ushimaru T

更新日期：2020-04-09 00:00:00

abstract：:5-Aminosalicylic acid (5-ASA) is conventionally used as a first line drug for inflammatory bowel disease (IBD). Because 5-ASA is well absorbed in the small intestine, very high dose of 5-ASA is required to deliver it to the large intestine which is a target site. Interestingly, 5-ASA is reported to be transported into...

journal_title：Biochemical and biophysical research communications

authors： Yuri T,Kono Y,Fujita T

更新日期：2020-04-09 00:00:00

abstract：:Deoxyribozymes or DNAzyme are identified as catalytic DNA sequences which catalyze different chemical reactions. Ligating deoxyribozymes catalyze the formation of branched and linear products. Due to the lack of efficient read-out systems, there is no report on in vivo application of ligating deoxyribozymes. To expand...

journal_title：Biochemical and biophysical research communications

authors： Dehghanian F,Najafi ZB,Hojati Z,Javadi-Zarnaghi F

更新日期：2020-04-02 00:00:00

abstract：:As a typical organism of platyhelminth, Dugesia japonica attracts more and more attention for its strong regenerative ability. Protein arginine methyltransferase (PRMT) family is composed of a class of enzymes with methyltransferase activities, which play fundamental roles in vivo in many important physiological proce...

journal_title：Biochemical and biophysical research communications

authors： Zhang Y,Wu W,Gao L,Chen M,Liu X,Huang M,Li A,Zheng K,Liu D,Deng H,Zhao B,Liu B,Pang Q

更新日期：2020-04-02 00:00:00

abstract：:Hepatocellular carcinoma (HCC) tumors evade death in part by downregulating expression of the tumor suppressor gene Interferon regulatory factor-1 (IRF-1). However, the molecular mechanisms accounting for IRF-1 suppression in HCC have not been well described. In this study, we identified a novel microRNA-301a (miR-301...

journal_title：Biochemical and biophysical research communications

authors： Dong K,Du Q,Cui X,Wan P,Kaltenmeier C,Luo J,Yan B,Yan Y,Geller DA

更新日期：2020-04-02 00:00:00

abstract：:Thick filaments from some striated muscles are regulated by phosphorylation of myosin regulatory light chains (RLCs). A tarantula thick filament quasi-atomic model achieved by cryo-electron microscopy has advanced our understanding on how this regulation occurs. In native thick filaments, an asymmetric intramolecular ...

journal_title：Biochemical and biophysical research communications

authors： Sulbarán G,Biasutto A,Méndez F,Pinto A,Alamo L,Padrón R

更新日期：2020-03-26 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is featured by hepatic steatosis, insulin resistance, lipid deposition and inflammation. However, the pathogenic mechanism of NAFLD is still poorly understood. Dual-specificity phosphatase 16 (DUSP16), a c-Jun N-terminal kinase-specific phosphatase, has been reported to negativ...

journal_title：Biochemical and biophysical research communications

authors： Wu YK,Hu LF,Lou DS,Wang BC,Tan J

更新日期：2020-03-26 00:00:00

abstract：:In normal development, the rate of cell differentiation is tightly controlled and critical for normal development and stem cell differentiation. However, the underlying mechanisms regulating the rate of the differentiation are unknown, and manipulation of the rate of the stem cell differentiation is currently difficul...

journal_title：Biochemical and biophysical research communications

authors： Minakawa T,Kanki Y,Nakamura K,Yamashita JK

更新日期：2020-03-26 00:00:00

abstract：:Gastric epithelial cells (GES-1) stimulated by Helicobacter pylori (H. pylori) would affect the expression of related genes and induce the immune response of the cells. Abnormal methylation of DNA was one of the main causes. The aim of this study was to investigate phosphoinositol-3-kinase adaptor protein 1(PIK3AP1), ...

journal_title：Biochemical and biophysical research communications

authors： Zhang A,Yan S,Cao M,Wu D,Zhou J,Yu Z,Wu M,Liu Y,Lu S,Hu G,Zhao J

更新日期：2020-03-26 00:00:00

abstract：:Activating Transcription Factor 2 (ATF2) is a member of the ATF/CREB bZIP family of transcription factors and an oncogene in prostate cancer. ATF2 has been reported to be a critical substrate of the CUL3-SPOP-RBX1 E3 ubiquitin ligase complex and the recurrent somatic mutation of SPOP has been believed to be a key feat...

journal_title：Biochemical and biophysical research communications

authors： Geng L,Chen X,Zhang M,Luo Z

更新日期：2020-03-26 00:00:00

abstract：:We report the functional and structural characterization of trehalose-6-phosphate phosphatase (TPP), from the Gram-negative bacterium B. pseudomallei that causes melioidosis, a severe infectious disease endemic in Southeast Asia and Northern Australia. TPP is a key enzyme in the trehalose biosynthesis pathway, which p...

journal_title：Biochemical and biophysical research communications

authors： Suthisawat S,Gourlay LJ,Bolognesi M,Boonyuen U,Vanaporn M

更新日期：2020-03-19 00:00:00

abstract：:Dasatinib, a second-generation tyrosine kinase inhibitor, is indicated for the therapy of imatinib-resistant leukemia and also for the treatment of solid cancers. Here, we report a novel effect of dasatinib of inducing differentiation in normal human melanocytes. Treatment with dasatinib significantly increased the me...

journal_title：Biochemical and biophysical research communications

authors： Kang B,Kim Y,Park TJ,Kang HY

更新日期：2020-03-19 00:00:00

abstract：:Parathyroid hormone (PTH) enhances cystic fibrosis transmembrane conductance regulator (CFTR)-mediated anion secretion by the human intestinal epithelial cell line Caco-2. With the patch-clamp and Ussing chamber techniques, we investigated how PTH stimulates CFTR activity in Caco-2 cells. Cell-attached recordings reve...

journal_title：Biochemical and biophysical research communications

authors： Jantarajit W,Wongdee K,Lertsuwan K,Teerapornpuntakit J,Aeimlapa R,Thongbunchoo J,Harvey BSJ,Sheppard DN,Charoenphandhu N

更新日期：2020-03-12 00:00:00

abstract：:Glycoprotein130 (gp130) is an important signal transducer in the interleukin-6 (IL-6) trans-signaling pathway, which plays a crucial role in chronic inflammation in atherosclerosis. Studies suggest that estrogen can inhibit IL-6/gp130 signaling and reduce the risk of coronary artery disease, but the precise mechanism ...

journal_title：Biochemical and biophysical research communications

authors： Zhou M,Dai W,Cui Y,Li Y

更新日期：2020-03-12 00:00:00

abstract：:Age-related hearing loss (ARHL) is a neurodegenerative disease associated with an aged population. ARHL is influenced by biological factors such as aging, sex difference, and atherosclerosis. The mechanisms of ARHL caused by atherosclerosis have not been previously determined in apolipoprotein E knockout (ApoE KO) mal...

journal_title：Biochemical and biophysical research communications

authors： Kim YY,Chao JR,Kim C,Kim B,Thi-Thanh Nguyen P,Jung H,Chang J,Lee JH,Suh JG

更新日期：2020-03-12 00:00:00

abstract：:Betulinic acid (BA) exhibits various biological activities such as anti-bacterial, anti-inflammatory, anti-human papilloma virus (HPV), and anti-cancer activities. HPV infection is associated with a high risk of cervical cancer, which is the leading cause of deaths among women worldwide. Therefore, BA is an attractive...

journal_title：Biochemical and biophysical research communications

authors： Kim HJ,Cho HS,Ban HS,Nakamura H

更新日期：2020-03-12 00:00:00

abstract：:CREB3 (Luman) is a family member of ER resident transcription factors, which are cleaved upon the induction of ER stress. Their N-terminal fragments shuttle into the nucleus where they regulate the transcription of target genes. Here, we found that human CREB3 is phosphorylated within its transcription activation doma...

journal_title：Biochemical and biophysical research communications

authors： Schmitt BM,Ampofo E,Stumpf H,Montenarh M,Götz C

更新日期：2020-03-12 00:00:00

abstract：:Neonatal hypoxia can induce the persisting brain dysfunctions and subsequently result in the behavioral abnormalities in adulthood. Improving mitochondrial functions were suggested as the effective strategy for brain functional recovery. In this study, we tested the effects of physical exercise, a well-established way...

journal_title：Biochemical and biophysical research communications

authors： Sun L,Ye R,Liang R,Xing F

更新日期：2020-03-05 00:00:00

abstract：:Recent progress in the field of mesenchymal stem cell (MSC) biology has enabled their clinical application. In the autologous cell transplantation therapy, the source of MSCs are quite important to reduce patients' physical burden. In this study, we isolated MSCs from the synovial fluid (SF) and synovial membrane (Syn...

journal_title：Biochemical and biophysical research communications

authors： Amemiya M,Tsuji K,Katagiri H,Miyatake K,Nakagawa Y,Sekiya I,Muneta T,Koga H

更新日期：2020-03-05 00:00:00

abstract：:The development of head and neck squamous cell carcinoma (HNSCC) is a complex pathological process and many cellular and molecular events may occur. The ubiquitin conjugating enzyme E2 (UBE2C) was found to play an oncogenic role in several human cancers. However, its functional role in HNSCC tumorigenesis remains unkn...

journal_title：Biochemical and biophysical research communications

authors： Jin Z,Zhao X,Cui L,Xu X,Zhao Y,Younai F,Messadi D,Hu S

更新日期：2020-03-05 00:00:00

abstract：:Protein cages have recently emerged as an extraordinary drug-delivery system due to its biocompatibility, biodegradability, low toxicity, ease to manipulate and engineer. We have reported earlier the formation and architecture of a do-decameric cage-like architecture of Vibrio cholerae acylphosphatase (VcAcP) at 3.1 Å...

journal_title：Biochemical and biophysical research communications

authors： Chatterjee S,Nath S,Sen U

更新日期：2020-03-05 00:00:00

abstract：:Diverse inner arm dyneins cooperate with outer arm dyneins to produce ciliary beating. This study demonstrates an expression system for inner arm dyneins in Tetrahymena. The motor domain of inner arm dynein (Dyh8p or Dyh12p) was fused with the tail of outer arm dynein (Dyh3p) and expressed in viable DYH3-knockout (vKO...

journal_title：Biochemical and biophysical research communications

authors： Edamatsu M

更新日期：2020-02-26 00:00:00

abstract：:Histone deacetylase (HDAC) 10 is a member of class IIb HDACs, but its deacetylation targets and functions are poorly characterized. Recent investigation has proposed that HDAC10 deacetylates heat shock cognate protein 70 kDa (HSC70) after interaction. HSC70 plays an important role in chaperone-mediated autophagy (CMA)...

journal_title：Biochemical and biophysical research communications

authors： Obayashi H,Nagano Y,Takahashi T,Seki T,Tanaka S,Sakai N,Matsumoto M,Maruyama H

更新日期：2020-02-26 00:00:00

abstract：BACKGROUND:Mutations in the four and-a-half LIM domain protein 1 (FHL1) gene or FHL1 protein deletion have been identified as the cause of rare hereditary myopathies or cardiomyopathies. In our previous study, autophagy activation was associated with myofibrillar abnormalities in FHL1 knockout (KO) mice. P2RX7 induces ...

journal_title：Biochemical and biophysical research communications

authors： Ding J,Cong Y,Li F,Liu B,Wu D,Miao J,Wang L

更新日期：2020-02-26 00:00:00

abstract：:Triple-negative breast cancer (TNBC) represents a unique subgroup of breast cancers (BCa) with potential to be highly proliferative and invasive. Patient with TNBC are prone to developing resistance to chemotherapy. Therefore, TNBC usually has a poor clinical outcome. The key factors driving these malignant features r...

journal_title：Biochemical and biophysical research communications

authors： Wang H,Yang T,Yuan Y,Sun X

更新日期：2020-02-26 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic, chronic inflammatory disease that is characterized by T helper 17 (Th17) cell- and osteoclast-induced joint destruction and inflammation. In RA, several cytokines (interleukin (IL)-1, 6,17, and tumor necrosis factor (TNF)) are involved in almost all aspects of articular inflamm...

journal_title：Biochemical and biophysical research communications

authors： Park YH,Kim HJ,Lee K,Choi Y,Heo TH

更新日期：2020-02-19 00:00:00